Functional adaptivity for digital library services in e-infrastructures: the gCube approach

We consider the problem of e-Infrastructures that wish to reconcile the generality of their services with the bespoke requirements of diverse user communities. We motivate the requirement of functional adaptivity in the context of gCube, a service-based system that integrates Grid and Digital Library technologies to deploy, operate, and monitor Virtual Research Environments defined over infrastructural resources. We argue that adaptivity requires mapping service interfaces onto multiple implementations, truly alternative interpretations of the same functionality. We then analyse two design solutions in which the alternative implementations are, respectively, full-fledged services and local components of a single service. We associate the latter with lower development costs and increased binding flexibility, and outline a strategy to deploy them dynamically as the payload of service plugins. The result is an infrastructure in which services exhibit multiple behaviours, know how to select the most appropriate behaviour, and can seamlessly learn new behaviours

The essential oil of Thymbra capitata and its application as a biocide on stone and derived surfaces

Many chemicals used nowadays for the preservation of cultural heritage pose a risk to both human health and the environment. Thus, it is desirable to find new and eco-friendly biocides that can replace the synthetic ones. In this regard, plant essential oils represent effective alternatives to synthetic substances for the preservation of historical monuments. Thymbra capitata (syn. Thymus capitatus) is a medicinal and aromatic plant growing in the Mediterranean area and endowed with important pharmacological properties related to its essential oil. Among them, the antimicrobial ones make the T. capitata essential oil an ideal candidate for industrial applications; for instance, as biocide for the inhibition and elimination of biological patinas of cyanobacteria and green algae on historical monuments. In the present work, we studied the chemical composition of the essential oil from T. capitata growing in Malta by gas chromatography-mass spectrometry (GC/MS). The major volatile component is the phenolic monoterpene carvacrol (73.2%), which is capable of damaging the cytoplasmic membrane and to interfere both in the growth curve and in the invasive capacity, though the contribution of minor components γ-terpinene and p-cymene cannot be disregarded. For the oil application on the stone surface, Pickering emulsions systems were prepared with an essential oil/water 1:3 mass ratio stabilized with kaolinite at 4 mass% in the presence of Laponite®; this allowed to limit the fast volatility of the oil and guaranteed a better application and an easier removal from the artefacts attacked by biodeteriogens both indoor and outdoor. This formulation caused the elimination of biodeteriogens from treated surfaces without residuals or films on artworks surface, and the effect was retained up to four months

Classification and imaging of ankle impingement syndromes.

Learning Objectives: To review the classification of ankle impingement syndromes. To describe and illustrate the spectrum of appearance of ankle impingement syndromes using conventional radiography (CR), multidetector computed tomography (MDCT), ultrasonography (US), magnetic resonance imaging (MRI), and MR arthrography (MRA). Background: Ankle impingement syndromes are a spectrum of diseases common in both athletic and general population and depend on many causes that can be distinguished by the type of tissue which determines the conflict (bone, fibrous, synovial). In general, classification of ankle impingement syndromes takes into account the anatomical site relative to the tibio-tarsal joint, and thus they may be classified as anterior, antero-medial, antero-lateral, posterior and postero-medial. Imaging findings: CR alone already suffices to demonstrate a bone impingement in most cases, while there is necessity to use MDCT where the site of impingement is in an anatomical site not clearly demonstrable by CR because of the presence of superimposed structures. US has the ability to recognize the presence of an anterior impingement and it may assess tendon disorders (stenosing tenosynovitis) which may be an associate sign of an impingement syndrome. MRI is the method of choice to assess synovial or fibrous impingement syndromes thanks to its excellent contrast resolution. MRA is used when there is capsular thickening that could not be detected by simple MRI. Conclusion: Diagnostic imaging has a very important role in the recognition of the cause of impingement and of the anatomical site where such a conflict takes place, thus allowing a correct therapeutic management

Physical activity and mobility function in elderly people living in residential care facilities. “Act on aging”: a pilot study

The present study aims at investigating the changes between pre-test and post-test in mobility function, balance, and gait after a physical activity program in a sample of elderly people. Forty-four individuals living in residential care facilities were recruited, with a mean age of 85 (SD = 6.6) in the control group and 84.26 (SD = 7.4) in the intervention group. We collected baseline and post-test measurements for the Tinetti Test. The findings showed that the physical activity intervention had a positive effect on physical functions. There was a statistically significant change between the means of the two groups over time; the intervention groups showed a stable condition with respect to overall mobility function, balance, and gait while the control group showed decreased performance at the post-test. These results underline that even in critical conditions, relatively simple training may promote a more positive adjustment to old age

Physical functioning: the mediating effect on ADLs and vitality in elderly living in residential care facilities. “Act on ageing”: a pilot study

The present study aims at verifying whether participation in a physical activity programme has positive effects on the daily life autonomy and vitality of elderly people living in residential care facilities by the mediation of their physical wellbeing. Fifty-one institutionalised individuals took part in the study. The control group included 11 people (84.26 ± 7.4 years), whereas the experimental group was made up of 40 people (85 ± 6.6 years). The experimental group was involved in a physical activity programme twice a week. The 36-Item Short Form Health Survey Questionnaire, the Activities of Daily Living Scale, and the Tinetti Test were administered to the participants. The linear regression method as well as Sobel’s formula were used for the analysis. The results show that participation in a physical activity programme has positive effects on autonomy in bathing and on the participants’ sense of vitality due to the mediation of physical functioning. These results confirm the importance of physical activity for the elderly populations living in residential care facilities

Evaluation of lumbar pain with weight-bearing MRI: Preliminary experience.

PURPOSE/INTRODUCTION: To assess the usefulness of weight-bearing examination of the lumbar spine performed with a dedicated MRI scanner in the evaluation of patients with clinical evidence of lumbar pain. MATERIALS AND METHODS: Between August 2008 and July 2009, 40 patients with clinical evidence of lumbar pain (group A) and a similar number of healthy volunteers (group B) were submitted to MRI examination of lumbar spine. Spin echo T1w and fast spin echo T2w images were acquired with a 0.25 Tesla scanner (G-Scan, Esaote Spa, Genoa, Italy) in both weight-bearing position and conventional supine position. A dedicated receiving coil for the lumbar spine was used. Three radiologists, blinded on history and clinical examination of subjects, assessed, in consensus, variations of lumbar lordosis angle and presence of pathology on images acquired in both positions, in different sequences and in different planes. RESULTS: In group A, conventional supine MRI was positive for pathology in 30/40 cases while weight-bearing MRI was positive in 39/40 cases. In all cases of group B, no signs of pathology was found in both positions. Weight-bearing MRI showed modifications of lumbar lordosis angle in all cases of both groups in respect to conventional supine MRI. DISCUSSION/CONCLUSION: Imaging the lumbar spine in weight-bearing position with a dedicated MRI scanner and a dedicated coil could allow identification of pathology which could be overlooked if imaging patients only in the supine position

Hsp70 localizes differently from chaperone Hsc70 in mouse mesoangioblasts under physiological growth conditions.

Mouse A6 mesoangioblasts express Hsp70 even in the absence of cellular stress. Its expression and its intracellular localization were investigated under normal growth conditions and under hyperthermic stress. Immunofluorescence assays indicated that without any stress a fraction of Hsp70 co-localized with actin microfilaments, in the cell cortex and in the contractile ring of dividing cells, while the Hsc70 chaperone did not. Hsp70 immunoprecipitation assays confirmed that a portion of Hsp70 binds actin. Immunoblot assays showed that both proteins were present in the nucleus. After heat treatment Hsp70 and actin continued to co-localize in the leading edge of A6 cells but not on microfilaments. Although Hsp70 and Hsc70 are both basally synthesized they showed different cellular distribution, suggesting an Hsp70 different activity respect to the Hsc70 chaperone. Moreover, we found Hsp70 in the culture medium as it has been described in other cell types